Gene name:
Slc11a2 (Dct1;Dmt1;Nramp2) ;
Protein name:
Natural resistance-associated macrophage protein 2 (NRAMP 2) ;
Alternative:
Divalent metal transporter 1 (DMT-1) ;Divalent cation transporter 1 ;Solute carrier family 11 member 2 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Forms a complex with NDFIP1 and NEDD4L, in cortical neurons, in response to iron and colbalt exposure; this interaction leads to ubiquitination by NEDD4L and proteasome-dependent degradation. Interacts with NDFIP2.
Function:
Important in metal transport, in particular iron. Involved in apical iron uptake into duodenal enterocytes. Involved in iron transport from acidified endosomes into the cytoplasm of erythroid precursor cells. May play an important role in hepatic iron accumulation and tissue iron distribution.
Subcellular Location:
Endosome membrane
Multi-pass membrane protein
Protein Attributes:
50:
MVLDPKEKMP | DDGASGDHGD | SASLGAINPA | YSNSSLPHST | GDSEEPFTTY |
100:
FDEKIPIPEE | EYSCFSFRKL | WAFTGPGFLM | SIAYLDPGNI | ESDLQSGAVA |
150:
GFKLLWVLLL | ATIVGLLLQR | LAARLGVVTG | LHLAEVCHRQ | YPKVPRIILW |
200:
LMVELAIIGS | DMQEVIGSAI | AINLLSAGRV | PLWGGVLITI | ADTFVFLFLD |
250:
KYGLRKLEAF | FGFLITIMAL | TFGYEYITVK | PSQSQVLRGM | FVPSCPGCRT |
300:
PQVEQAVGIV | GAVIMPHNMY | LHSALVKSRQ | VNRANKQEVR | EANKYFFIES |
350:
CIALFVSFII | NVFVVSVFAE | AFFEKTNKQV | VEVCKNNSSP | HADLFPSDNS |
400:
TLAVDIYKGG | VVLGCYFGPA | ALYIWAVGIL | AAGQSSTMTG | TYSGQFVMEG |
450:
FLNLKWSRFA | RVILTRSIAI | IPTLLVAVFQ | DVEHLTGMND | FLNVLQSLQL |
500:
PFALIPILTF | TSLRPVMSEF | SNGIGWRIAG | GILVLIVCSI | NMYFVVVYVQ |
550:
ELGHVALYVV | AAVVSVAYLT | FVFYLGWQCL | IALGLSFLDC | GRSYRLGLTA |
568:
QPELYLLNTV | DADSVVSR
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Rat
Human
Mouse
ELISA Kit for Mouse NRAMP 2
ELISA Kit for Mouse NRAMP 2
ELISA Kit for Mouse NRAMP 2
CLIA Kit for Mouse NRAMP 2
CLIA Kit for Mouse NRAMP 2
CLIA Kit for Mouse NRAMP 2
Polyclonal Antibody for Mouse NRAMP 2
Polyclonal Antibody for Mouse NRAMP 2
Polyclonal Antibody for Mouse NRAMP 2
Monoclonal Antibody for Mouse NRAMP 2
Monoclonal Antibody for Mouse NRAMP 2
Monoclonal Antibody for Mouse NRAMP 2
Protein for Mouse NRAMP 2
Protein for Mouse NRAMP 2
Protein for Mouse NRAMP 2
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
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DBA .
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Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
strain :
C57BL/6J .
tissue :
Embryo .
tissue :
Hippocampus .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
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FVB/N .
tissue :
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] OF 1-80 (ISOFORMS 3/4);ALTERNATIVE SPLICING
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C57BL/6 .
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Duodenum .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT MK ARG-185